Nanoparticle Research

Leverage the power of flow cytometry for the detection and characterization of cellular origin nanoparticles

Interest in nanoparticles and extracellular vesicles of cellular origin is exploding due to new insights into the role these particles play in extracellular communication processes and the potential for detecting pathological states via liquid biopsy.

Several fundamental capabilities of flow cytometry make this an attractive platform for extracellular vesicle research, such as the ability to detect large numbers of events and discriminate rare events while collecting information on surface composition.

Recent developments in laser and electronics design pushed the boundaries of reliably detecting events in the nanoparticle size range. The newest member of the CytoFLEX Platform, the CytoFLEX nano Flow Cytometer is the first benchtop instrument with acceptable noise-to-signal discrimination for the reliable detection of particles down to 80 nm. 

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Extracellular Vesicles for ‘Liquid Biopsy’ Development in Cancer by Dr. Karla Williams Using nano-scale flow cytometry, the Williams lab has identified a secondary bio-marker that allows them to identify the most critical prostrate cancer in patient samples. This revolutionary discovery has the potential to reduce unnecessary needle biopsy surgeries because only a blood sample is needed, as well as reduce overall costs to test for the disease. The Williams lab expects to move to clinical trial phase in the coming months. 
Detection of Microparticles with Flow Cytometry
Large Scale Purification of RNA and RNA-based Nanoparticles by Preparative Ultracentrifugation Webinar from Daniel Jasinski covers RNA nanotechnology in cancer therapy. RNA/RNA-based nanoparticle purification by ultracentrifugation including current technologies, different methods of ultracentrifugation, why large quantities of RNA are needed, methods for large-scale RNA purification.
Looking Under the Hood: Getting Started with the Optima AUC In the webinar we discuss the fundamentals of analytical ultracentrifugation and look at a few sample applications.
Webinar: An Intro to Characterization of Biomolecules Using AUC Analytical Ultracentrifugation (AUC) is one of the most powerful biophysical tools used today for the characterization of biological samples ranging from small drug molecules to intact viruses, vesicles and microparticles

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