CD105 Antigen

The CD105 antigen, also called Endoglin, is a 170-180 kDa RGD containing molecule which is present on the cell surface as a disulphide-linked homodimer. The molecule is a co-receptor for Transforming Growth Factor (TGF) β1 and β3. It is expressed mainly on endothelial cells, but also strongly in pre-B lymphocytes and in a subpopulation of monocytes. CD105 is a regulatory protein of TGF-beta receptor complex. CD105 expression and function in primitive hematopoiesis indicate that this molecule could cooperate with the dissociation of TGF-β1 cell cycle effects from its other effects on cell survival and differentiation.