CD208 (DC-LAMP) Antigen

The DC-LAMP antigen (70-90 kDa) is a new member of the LAMP (lysosome-associated membrane protein) family. As other LAMP members such as CD68, DC-LAMP is a type I integral membrane protein of 416 amino acid residues, highly glycosylated (7 N- and some O-glycosylation sites), with 90% of the molecule located in the lumen of lysosomes. DC-LAMP is specifically expressed by those mature dendritic cells (DC) located in T cell areas of lymphoid tissues, which are known as interdigitating dendritic cells (IDC). A direct correlation between the expression of  DC-LAMP and that of other maturation markers such as CD86 has been established. DC-LAMP first appears in the MHC Class II compartment, suggesting an important contribution of DC-LAMP to the processing of exogenous antigens.


 Clone: 104.G4  Isotype: IgG1 Mouse

In flow cytometry, the 104.G4 antibody shows intracytoplasmic staining of DCs derived either from CD34+ cell cultures activated with TNFα and CD40L, or from monocyte cultures activated with TNFα, LPS and CD40L.
 

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Product Line Specifications

Format Liquid
Specificity CD208
Form UNLB
Clone 104.G4
Isotype IgG1 Mouse
Target Species Human
Item Specifications Referenced IM3448

The specifications above are not representative of all reagents but only to the item/part number referenced in this Product Line Specifications table. Please view a product's detail page to view all product specifications for that particular reagent. 


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