The CD37 antigen is a 40-52 kDa single chain transmembrane protein with 4 transmembrane domains (Tetraspan/TM4SF). It has both its NH2- and COOH-termini inside the cells, and is heavily glycosylated on one extracellular loop. Its main feature is its high content of hydrophobic residues (45%). CD37 is strongly expressed on the surface of human peripheral blood B lymphocytes and on B cells from germinal centers. In the ontogeny of B cells, this antigen appears late, after the pre-B stage, and is not expressed on plasma cells. CD37 has a low expression on T lymphocytes, granulocytes, and monocytes. It is weakly expressed by other cellular types such as Langerhans cells, macrophages, normal medullar granulous cells and peripheral blood polymorphonuclear cells. CD37 is involved in signal transduction.
|Clone: BL14||Isotype: IgG1 Mouse|
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Product Line Specifications
|Flow Product Line||IOTest|
|Item Specifications Referenced||IM0458|
The specifications above are not representative of all reagents but only to the item/part number referenced in this Product Line Specifications table. Please view a product's detail page to view all product specifications for that particular reagent.